Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold

Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Updates on Endothelial Functions of Proangiogenic Prokineticin.

Coronary and renal blood flows are important for maintaining cardiac and renal function. Endothelial cells (ECs) play critical roles in forming new vessels and regulating vessel functions. ECs also protect the surrounding tissues by secreting a variety of biologically active substances. Endothelial dysfunction occurs in various forms of cardiovascular and renal diseases. It plays a fundamental ...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

نارسایی طولانی مدت عملکرد کلیه در بیماران پیوندی با اختلال عملکرد مزمن

  HR Khalkhali [1] , MSc E Hajizadeh [2] , PhD A Ghafari Moghadam [3] , MD A Kazemnezhad [4] , PhD Morad Hajiyan [5] , MSc     Received: 21 April, 2009 Accepted: 22 July, 2009  Abstract  Background & Aims: Chronic Allograft Dysfunction is a major concern for graft loss in Renal Transplant Recipients. This paper investigated the waiting time and death-censored graft survival in renal transplant ...

Endothelial dysfunction and inflammation: what is the link?

Cardiovascular disease, resulting from arteriosclerotic remodeling of the vasculature, is the main cause of death in end-stage renal disease (ESRD) patients. Early during the course of arteriosclerosis, endothelial dysfunction can be detected in various vascular beds, including peripheral forearm arteries, as well as the coronary circulation. Furthermore, endothelial dysfunction seems to predic...